Symptom Tracker

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SENSORIMOTOR NEUROPATHY
CARDIAC
AUTONOMIC DYSFUNCTION
NEPHROPATHY
PAINFUL NEUROPATHY
MUSCULOSKELETAL
MUSCLE WEAKNESS AND FALLS
CO-MORBIDITIES
OTHER SYMPTOMS
SENSORIMOTOR NEUROPATHY
CARDIAC
ATRIAL FIBRILLATION
BRADYARRHYTHMIAS/
CONDUCTION
ABNORMALITIES/
PACEMAKERS
HEART FAILURE
AUTONOMIC DYSFUNCTION
NEPHROPATHY
MUSCULOSKELETAL
CO-MORBIDITIES
OTHER SYMPTOMS
SENSORIMOTOR NEUROPATHY
CARDIAC
RUPTURED BICEPS TENDON/POPEYE SIGN
AUTONOMIC DYSFUNCTION
NEPHROPATHY
BACK PAIN/LUMBAR SPINAL STENOSIS
TRIGGER FINGER
BILATERAL CARPAL TUNNEL SYNDROME
MUSCULOSKELETAL
SHOULDER, KNEE, AND HIP PAIN OR SURGERY
CO-MORBIDITIES
OTHER SYMPTOMS
SENSORIMOTOR NEUROPATHY
CARDIAC
AUTONOMIC DYSFUNCTION
NEPHROPATHY
MUSCULOSKELETAL
ORTHOSTATIC HYPOTENSION/
INTOLERANCE
TO BLOOD PRESSURE MEDICATIONS
CHRONIC DIARRHEA/CONSTIPATION/WEIGHT LOSS
ERECTILE DYSFUNCTION
CO-MORBIDITIES
OTHER SYMPTOMS
SENSORIMOTOR NEUROPATHY
CARDIAC
AUTONOMIC DYSFUNCTION
NEPHROPATHY
MUSCULOSKELETAL
RENAL FAILURE
PROTEINURIA
CO-MORBIDITIES
OTHER SYMPTOMS
SENSORIMOTOR NEUROPATHY
CARDIAC
AUTONOMIC DYSFUNCTION
NEPHROPATHY
MUSCULOSKELETAL
CO-MORBIDITIES
OTHER SYMPTOMS
SENSORIMOTOR NEUROPATHY
CARDIAC
AUTONOMIC DYSFUNCTION
NEPHROPATHY
MUSCULOSKELETAL
CO-MORBIDITIES
OTHER SYMPTOMS

SENSORIMOTOR NEUROPATHY1-3

Painful neuropathy in hands and feet
Muscle weakness, difficulty walking, and falls

CARDIAC1-3

Heart failure
Atrial fibrillation
Bradyarrhythmias/ conduction abnormalities/ pacemakers

MUSCULOSKELETAL1-3

Back pain/lumbar spinal stenosis
Ruptured biceps tendon/Popeye sign
Shoulder, knee, and hip pain or surgery
Trigger finger
Bilateral carpal tunnel syndrome

AUTONOMIC DYSFUNCTION1-3

Orthostatic hypotension/ intolerance to blood pressure medications
Chronic diarrhea/ constipation/weight loss
Erectile dysfunction

NEPHROPATHY1-3

Proteinuria
Renal failure

CO-MORBIDITIES

Some co-morbidities are often referred to as idiopathic (i.e. before an amyloidosis diagnosis some symptoms would seem to have no apparent cause)

OTHER SYMPTOMS

Carpal tunnel syndrome
Severe fatigue
An enlarged tongue, which sometimes looks rippled around its edge
Eye involvement (e.g., vitreous opacities)
Shortness of breath

References: 1. Nativi‑Nicolau JN, Karam C, Khella S, Maurer MS. Screening for ATTR amyloidosis in the clinic: overlapping disorders, misdiagnosis, and multiorgan awareness. Heart Fail Rev. 2022;27(3):785-793. 2. Gertz MA. Hereditary ATTR amyloidosis: burden of illness and diagnostic challenges. Am J Manag Care. 2017;23(7 Suppl):S107-S112. 3. Adams D, Algalarrondo V, Polydefkis M, Sarswat N, Slama MS, Nativi-Nicolau J. Expert opinion on monitoring symptomatic hereditary transthyretin-mediated amyloidosis and assessment of disease progression. Orphanet J Rare Dis. 2021;16(1):411. 4. Gertz M, Adams D, Ando Y, et al. Avoiding misdiagnosis: expert consensus recommendations for the suspicion and diagnosis of transthyretin amyloidosis for the general practitioner. BMC Fam Pract. 2020;21(1):198. 5. Bazell C, Alston M, Kumar N, et al. Descriptive characteristics of patients diagnosed with transthyretin amyloidosis (ATTR) in the Medicare fee-for-service and commercial populations [abstract and poster]. International Symposium of Amyloidosis; May 26-30, 2024; Rochester, MN. 6. Berk JL, Suhr OB, Obici L, et al. Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial. JAMA. 2013;310(24):2658-2667. 7. Conceição I, González-Duarte A, Obici L, et al. “Red-flag” symptom clusters in transthyretin familial amyloid polyneuropathy. J Peripher Nerv Syst. 2016;21(1):5-9. 8. Kittleson MM, Ruberg FL, Ambardekar AV, et al; Writing Committee. 2023 ACC Expert Consensus Decision Pathway on comprehensive multidisciplinary care for the patient with cardiac amyloidosis: a report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2023;81(11):1076-1126.