Digital Patient Checklist
Transthyretin amyloidosis (ATTR) is a progressive, multi-system disease caused by the misfolding of the transthyretin (TTR) protein, which is primarily produced in the liver. TTR normally functions to transport thyroxine and retinol-binding protein. However, in ATTR, either due to genetic mutations (hereditary ATTR, or hATTR) or age-related changes (wild-type ATTR or wt-ATTR), TTR tetramers dissociate into monomers that misfold and gather into amyloid fibrils. These fibrils deposit in various tissues, leading to organ dysfunction.
Diagnostic Tool
A delay in diagnosis can have lasting consequences. See what diagnostic tools are available in Canada.
Symptom Tracker
ATTR has a broad range of symptoms that may seem unrelated. Visit our symptom tracker to see if your symptoms may be related to ATTR.
Management Options
Management options are available for patients diagnosed with both hATTR and wt-ATTR. See what options are available to you.
Appointment Preparation
Preparing for appointments with your physician is important. See what are the common questions you may need to ask your doctor during your appointment.